The Society of Cells
The Biology of Cancer (Second Edition)
The Biology of Cancer (Second
The definitive text on cancer biology, thoroughly updated Incorporating the most important advances in the fast-growing field of cancer biology, the text maintains all of its hallmark features. It is admired by students, instructors, researchers, and clinicians around the world for its clear writing, extensive full-color art program, and numerous pedagogical features.
- Brand: imusti
- ASIN: 0815342195
The Genetics of Cancer: Genes Associated with Cancer Invasion, Metastasis and Cell Proliferation
The Genetics of Cancer: Genes Associated with Cancer
Written by internationally recognized experts, The Genetics of Cancer provides up-to-date information and insight into the genetic basis of cancer and the mechanisms involved in cancer invasion and its secondary spread. This volume presents the deregulation of the cell cycle in tumor development and integrates the function of tumor suppressor genes, oncogenes, and metastasis-associated genes in the pathogenesis and progression of cancer. The Genetics of Cancer will be useful to all graduate students, clinicians, and researchers working in the fields of cancer biology, genetics, and molecular biology.Clonal evolution of the metastasis phenotypeCell Cycle regulationApoptosis in tumour growth and metastasisAngiogenesis in cancerCell surface glycoproteins and their receptorsProteinases and their inhibitors in cancer invasionOncogenes and cancer metastasisDevelopmental genesTumour suppressor genesMetastasis suppressor genesDominant metastasis-associated genes
- ASIN: 0126398755
Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy (Elsevier Insights)
Growth Factors and Their Receptors in Cell Differentiation,
Recent years have seen a considerable emphasis on growth factors and the elucidation of their mode of function, which has led to the recognition that growth factors, their receptors as well as downstream elements of signalling associated with their function might be potential targets in therapeutic management of human diseases. Humanised monoclonal antibodies raised against growth factor receptors have proved to be valuable for targeted cancer treatment and in patient management. This book reviews the latest developments providing insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment.Provides a fundamental understanding of the basic functions of growth factors and their receptors, describing how they are linked in biological processesAids the development of therapeutic treatments for cancerFocuses on the interrelationships and convergence of growth factors and their receptors in development and pathogenesis and encourages greater cooperation and integration in the areas of developmental, cancer and cancer therapeutic research
- ASIN: 0123878195
Cancer Stem Cells: Philosophy and Therapies
Cancer Stem Cells: Philosophy and
An innovative theory proposes a new therapeutic strategy to break the stalemate in the war on cancer. It is called cancer stem cell (CSC) theory, and Lucie Laplane offers a comprehensive analysis, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy.Rather than treat cancer by aggressively trying to eliminate all cancerous cells―with harmful side effects for patients―CSC theory suggests the possibility of targeting the CSCs, a small fraction of cells that lie at the root of cancers. CSCs are cancer cells that also have the defining properties of stem cells―the abilities to self-renew and to differentiate. According to this theory, only CSCs and no other cancer cells can induce tumor formation.To date, researchers have not agreed on the defining feature of CSCs―their stemness. Drawing from a philosophical perspective, Laplane shows that there are four possible ways to understand this property: stemness can be categorical (an intrinsic property of stem cells), dispositional (an intrinsic property whose expression depends on external stimuli), relational (an extrinsic property determined by a cell’s relationship with the microenvironment), or systemic (an extrinsic property controlled at the system level). Our ability to...
- ASIN: 0674088743
Textbook of Cell Signalling in Cancer: An Educational Approach
Textbook of Cell Signalling in Cancer: An Educational
This book provides a simplified, yet comprehensive, overview of the signalling pathways operating between and inside cells, which will help younger oncologists find their way in the labyrinth of signalling pathways and in the multitude of signals and signal receptors, transducers and effectors that contribute to oncogenesis.This comprehensive reference text is based on the master’s courses delivered by Prof. Jacques Robert to graduate students at the University of Bordeaux, France. It includes a large number of colour schemas and figures that have been improved year after year for educational purposes. Signalling pathways are described individually and in depth, but without ignoring the multiplicity of interconnections and crosstalk. The presentation of each pathway is followed by a brief description of the alterations found in cancers as well as of the targeted pharmacological approaches that can be used to prevent or overcome the consequences of these oncogenic alterations. The basic mechanisms of molecular biology at the DNA replication, RNA transcription and protein activity levels are presented in a series of didactic annexes, enabling readers to better understand the alterations in signalling pathways.
- ASIN: 3319345710
Basic Science of Oncology, Fifth Edition (McGraw-Hill International Editions)
Basic Science of Oncology, Fifth Edition (McGraw-Hill International
Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product.NOW IN FULL COLOR!Discover the science of cancer--with this newly revised, essential introduction to cancer biology and geneticsA Doody's Core Title for 2015!Here in one well-organized, reader-friendly volume, you'll find everything you must know about the biology underlying cancer and its treatment, supported by the latest peer-reviewed research. Written by preeminent oncology researchers and clinicians, the book highlights the full range of important oncology topics and takesyou through the biological basis of current and future biological therapy as well as more traditional approaches to cancer treatment.Presented in full color, the Fifth Edition of The Basic Science of Oncology is thoroughly updated and refreshed to reflect the latest critical thinking in oncology. For graduate students, oncologists, residents, and fellows, there can be no more useful guide to thebedrock science and practice of oncology than this all-in-one reference.This is a 2015 Doody's Core title.FEATURES:The most current, evidence-based oncology primer--one that encapsulates the science of cancer causation, cancer biolo...
- Brand: Brand: McGraw-Hill Professional
- ASIN: 0071745203
Essential Cell Biology + Garland Science Learning System Redemption Code
Essential Cell Biology + Garland Science Learning System
Essential Cell Biology provides a readily accessible introduction to the central concepts of cell biology, and its lively, clear writing and exceptional illustrations make it the ideal textbook for a first course in both cell and molecular biology. The text and figures are easy-to-follow, accurate, clear, and engaging for the introductory student. Molecular detail has been kept to a minimum in order to provide the reader with a cohesive conceptual framework for the basic science that underlies our current understanding of all of biology, including the biomedical sciences. The Fourth Edition has been thoroughly revised, and covers the latest developments in this fast-moving field, yet retains the academic level and length of the previous edition. The book is accompanied by a rich package of online student and instructor resources, including over 130 narrated movies, an expanded and updated Question Bank. Essential Cell Biology, Fourth Edition is additionally supported by the Garland Science Learning System. This homework platform is designed to evaluate and improve student performance and allows instructors to select assignments on specific topics and review the performance of the entire class, as well as individual students, via the instructor dashboard. Students receive immedia...
- ASIN: 0815345739
Molecular characterization of TGF? mediated cancer cell proliferation: TGF? Switch in Cancer
Molecular characterization of TGF? mediated cancer cell proliferation:
TGF? has a dual role in carcinogenesis, acting as a growth inhibitor in early tumor stages and a promoter of cell proliferation in advanced diseases. Although this cellular phenomenon is well established, the underlying molecular mechanisms remain elusive. Here, we report that sequential induction of NFAT and c-Myc transcription factors is sufficient and required for the TGF? switch from a cell cycle inhibitor to a growth promoter pathway in cancer cells. TGF? induces the expression and activation of NFAT factors, which then translocate into the nucleus to promote c-Myc expression. In response to TGF?, activated NFAT factors bind to and displace Smad3 repressor complexes from the c-Myc promoter. c-Myc in turn stimulates cell cycle progression and growth through up-regulation of D-type cyclins. Most importantly, NFAT knockdown not only prevents c-Myc activation and cell proliferation, but also partially restores TGF-beta-induced cell cycle arrest and growth suppression. Taken together, this study provides the first evidence for a Smad-independent master regulatory pathway in TGF?-promoted cell growth that is defined by sequential transcriptional activation of NFAT and c-Myc factors.
- ASIN: 3639298012
Tutorials in Mathematical Biosciences III: Cell Cycle, Proliferation, and Cancer (Lecture Notes in Mathematics)
Tutorials in Mathematical Biosciences III: Cell Cycle, Proliferation,
This volume introduces some basic mathematical models for cell cycle, proliferation, cancer, and cancer therapy. Chapter 1 gives an overview of the modeling of the cell division cycle. Chapter 2 describes how tumor secretes growth factors to form new blood vessels in its vicinity, which provide it with nutrients it needs in order to grow. Chapter 3 explores the process that enables the tumor to invade the neighboring tissue. Chapter 4 models the interaction between a tumor and the immune system. Chapter 5 is concerned with chemotherapy; it uses concepts from control theory to minimize obstacles arising from drug resistance and from cell cycle dynamics. Finally, Chapter 6 reviews mathematical results for various cancer models.
- ASIN: 3540291628
Trends in Stem Cell Proliferation and Cancer Research (English and Bengali Edition)
Trends in Stem Cell Proliferation and Cancer Research
The book will discuss the molecular mechanisms of cancer diseases, stem cell proliferation and transformation into cancer cells beyond the physiological processes that occur in normal stem cell biology. Some of the key oncogenic events in cancer and their signaling pathways that regulate cell division cycle progression will be described considering prospects for using such knowledge in advanced cancer therapy. Each chapter shall provide an invaluable resource for information on the most current advances in the field, with discussion of controversial issues and areas of emerging importance
- Brand: Rodrigo Resende
- ASIN: 9400762100
Histamine in Normal and Cancer Cell Proliferation
MAEA, NT (MAEA, EMP, Macrophage erythroblast attacher, Cell proliferation-inducing gene 5 protein, Erythroblast macrophage protein, Human lung cancer oncogene 10 protein), 038055-200ul
MAEA, NT (MAEA, EMP, Macrophage erythroblast attacher, Cell
This gene product mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. This protein is an integral membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Two immunologically related isoforms of erythroblast macrophage protein with apparent molecular weights of 33 kD and 36 kD were detected in macrophage membranes; this gene encodes the larger isoform. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. Applications: Suitable for use in Western Blot, ELISA Recommended Dilution: ELISA: 1:1,000 Western Blot: 1:100-500 Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
- Brand: United States Biological
- ASIN: B00W6A4TRM
Cell Surface GRP78, a New Paradigm in Signal Transduction Biology
Cell Surface GRP78, a New Paradigm in Signal
Cell Surface GRP78, a New Paradigm in Signal Transduction Biology presents a new paradigm that has emerged in the past decade with the discovery that various intracellular proteins may acquire new functions as cell surface receptors. Two very prominent examples are ATP synthase and GRP78. While the role of cell surface ATP synthase has been reviewed in various books, this book directs its attention to the story of cell surface GRP78. Edited by the researcher who identified cell surface expression of the molecular chaperone GRP78 as a major factor in prostate cancer and other malignanciesPresents an in-depth treatment of the biological underpinnings of GRP78 and its connection to diseaseProvides four-color illustrations that facilitate the narrative
- ASIN: 0128123516
Anti-Estrogen Regulations of Macrophage Products that Influence Breast Cancer Cell Proliferation and Susceptibility to Apoptosis
Anti-Estrogen Regulation of Macrophage Products That Influence Breast Cancer Cell Proliferation and Susceptibility to Apoptosis
Compartmentalized Signaling and Breast Cancer Cell Proliferation
TIG3 - A Novel Inhibitor of Breast Cancer Cell Proliferation
The Role of PKC in Retinoic Acid Regulation of Human Mammary Cancer Cell Proliferation
Introduction to Cancer Biology (Part 1): Abnormal Signal Transduction
This animation is the first part of the series "An Introduction to Cancer Biology", and explains the mechanism of abnormal signal transduction resulting in uncontrolled cell proliferation. This animation also provides an overview of the potential targets of anticancer therapies.
Cancer: from a healthy cell to a cancer cell
In 5 minutes find out how and why a normal cell becomes a cancer cell: risk factors and treatment.
How Cancer Develops & Mutation
How does cancer develop? Learn how cancer grows and about mutation of cancer cells with Cancer Research UK. Watch this video to find out how cancer develops or learn more on our website: http://www.cancerresearchuk.org/about-cancer/what-is-cancer/how-cancers-grow The video explains how cancer ...